Kim Butts Pauly's Lab

Ultrasound-based Neuromodulation

 

Ultrasound can be used to stimulate or inhibit neuronal activity. We have studied ultrasound neuromodulation of the rodent with implanted EMG electrodes in the forelimbs. We showed in the first paper optimal parameters, with the conclusion that continuous wave works better than pulsed ultrasound and that higher frequencies require more intensity.

Our second paper demonstrated localization of the signal: there were differences in EMG responses in the neck and tail when the transducer was cranially placed vs. caudally placed.

IIn our third paper, we confirmed the frequency dependence over a wider range of frequencies and multiple transducers, with a key figure from the paper shown here. We looked at the shear and normal strains, the radiation force, pressure, intensity, cavitation index, and mechanical index, and found that cavitation index (Cavitation Index = Pressure/Frequency) best correlates with the mouse data.

FreqDepFigure

A more detailed summary of this paper "Frequency Dependence of Ultrasound Neurostimulation in the Mouse Brain" may be found HERE on the Radiological Sciences Laboratory (RSL) Website

Relevant Publications

King R, Brown J, Newsome W, Butts Pauly K, Effective parameters for ultrasound-induced in vivo neurostimulation, Ultrasound in Med. & Biol. 2013 Feb; 39(2):312-31. PMID 23219040

King R, Brown J, Butts Pauly K, Localization of Ultrasound Induced In-Vivo Neurostimulation in the Mouse Model, Ultrasound in Med and Biol, 2014 Jul;40(7):1512-22. PMID: 24642220

Ye P, Brown J, Butts Pauly K, Frequency Dependence of Ultrasound Neurostimulation in the Mouse Brain, Ultrasound in Medicine and Biology, 2016 Apr 15. PMID: 27090861

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