Kim Butts Pauly's Lab

MRgFUS of Cancer in Moving Organs

We have developing advanced techniques for MR-guided thermal ablation of the liver and other moving organs.

For the liver, we developed a temperature monitoring sequence suitable for RF ablation of the liver. To do this, we deloped a multibaseline gated navigated PRF thermometry sequence. It worked well in vivo, as demonstrated in the Holbrook Article and the third image here. In the first two images, we show MR-ARFI images of the focal spot and compare to the ultimate hot spot created with a longer sonication.


Relevant Publications

Holbrook AB, Ghanouni P, Santos JM, Dumoulin C, Medan Y, Pauly KB. Respiration based steering for high intensity focused ultrasound liver ablation. Magn Reson Med. 2014 Feb;71(2):797-806. PMID: 23460510 PMCID: PMC4040338

Holbrook A, Santos J, Kaye E, Rieke V, Butts Pauly K, Real-Time MR Thermometry for Monitoring HIFU Ablations of the Liver, MRM, 2010 Feb;63(2):365-73. PMID: 19950255.

Holbrook A, Ghanouni P, Santos J, Medan Y, Butts Pauly K, In Vivo MR Acoustic Radiation Force Imaging in the Porcine Liver, Medical Physics, 2011 Aug;38(9)

Vigen KK, Daniel BL, Pauly JM, Butts K. Triggered, navigated, multi-baseline method for proton resonance frequency temperature mapping with respiratory motion. Magn Reson Med. 2003 Nov;50(5):1003-10.

V. Rieke, K. Vigen, G. Sommer, B. Daniel, J. Pauly, K. Butts, Referenceless PRF Shift thermometry, MRM, 2004 Jun;51(6):1223-31.

Vigen K, Jarrard J, Rieke V, Frisoli J, Daniel B, Butts Pauly K, In Vivo Porcine Liver Radiofrequency Ablation with Simultaneous MR Temperature Imaging, JMRI, 2006; 23(4): p578-584.

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