Kim Butts Pauly's Lab

Cancer Immunotherapy and Epilepsy Treatment with Ultrasound-based BBB opening

Focused ultrasound in the presence of microbubbles opens the blood brain barrier in order to allow the delivery of drugs into the brain. We are studying this for brain cancer treatment and for epilepsy treatment. Here is an example image of a mouse with a brain tumor. On the left, there is no enhancement. On the right, the gadolinium contrast agent leaks into the brain through the open blood brain barrier. The gadolinium agent shortens the T1 and gives a bright signal on these T1-weighted images.

BBB

Relevant Publications

Abstracts Not Published Elsewhere

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